专利名称：HIGH SPECIFICITY GENOME EDITING USING
CHEMICALLY MODIFIED GUIDE RNAS
发明人：DELLINGER, Douglas, J.,RYAN, Daniel, E.,ROY,
Subhadeep,SAMPSON, Jeffrey, R.
申请号：EP17811048.2申请日：20170608公开号：EP3469084A1公开日：20190417
摘要：The present invention relates to guide RNAs having chemical modifications andtheir use in CRISPR-Cas systems. The chemically modified guide RNAs have enhancedspecificity for target polynucleotide sequences. The present invention also relates tomethods of using chemically modified guide RNAs for cleaving or nickingpolynucleotides, and for high specificity genome editing.
申请人：Agilent Technologies, Inc.
地址：5301 Stevens Creek Blvd. MS: 1A-PB Santa Clara, CA 95051-7201 US
国籍：US
代理机构：Grünecker Patent- und Rechtsanwälte PartG mbB
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