Monoclonal antibody for analysis and clearance of

专利名称：Monoclonal antibody for analysis and

clearance of polyethylene glycol andpolyethylene glycol-modified molecules

发明人：Steve Roffler,Tian-Lu Cheng,Pin Yi Wu申请号：US09810379申请日：20010316

公开号：US20010028881A1公开日：20011011

摘要：A novel anti-polyethylene glycol monoclonal antibody and its preparation aredisclosed. Such an antibody can be used for determining polyethylene glycol

concentration in vitro or accelerating the clearance of a polyethylene glycol containingcompound from the blood circulation in the human body thereby reducing the toxicityassociated with the polyethylene glycol containing conjugate. The antibody is particularlyuseful in cancer therapy where the therapeutic agent is selectively delivered to the tumorby increasing the tumor/blood ratio of the polyethylene glycol containing compound.

申请人：ACADEMIA SINICA

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